059 GREM1, FRZB AND DKK1 ARE HIGHLY SPECIFICMARKERS FOR ARTICULAR CARTILAGE WHICH PREVENT HYPERTROPHIC DIFFERENTIATION
نویسندگان
چکیده
منابع مشابه
GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors
INTRODUCTION Osteoarthritis is, at least in a subset of patients, associated with hypertrophic differentiation of articular chondrocytes. Recently, we identified the bone morphogenetic protein (BMP) and wingless-type MMTV integration site (WNT) signaling antagonists Gremlin 1 (GREM1), frizzled-related protein (FRZB) and dickkopf 1 homolog (Xenopus laevis) (DKK1) as articular cartilage's natural...
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Purpose: Osteoarthritis (OA) is a multifactorial disease characterized by progressive degradation of articular cartilage leading to loss of joint function. It affects several million people in the world. Currently there is no cure for OA. In a subset of patients OA is associated with hypertrophic differentiation of articular chondrocytes. This process normally occurs in the growth plate. Health...
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PURPOSE Hypertrophic differentiation of growth plate chondrocytes induces angiogenesis which alleviates hypoxia normally present in cartilage. In the current study, we aim to determine whether alleviation of hypoxia is merely a downstream effect of hypertrophic differentiation as previously described or whether alleviation of hypoxia and consequent changes in oxygen tension mediated signaling e...
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Endochondral ossification begins from the condensation and differentiation of mesenchymal cells into cartilage. The cartilage then goes through a program of cell proliferation, hypertrophic differentiation, calcification, apoptosis, and eventually is replaced by bone. Unlike most cartilage, articular cartilage is arrested before terminal hypertrophic differentiation. In this study, we showed th...
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Hypertrophic differentiation occurs during in vitro chondrogenesis of mesenchymal stem cells (MSCs), decreasing the quality of the cartilage construct. Previously we identified WNT pathway antagonists Dickkopf 1 homolog (DKK1) and frizzled-related protein (FRZB) as key factors in blocking hypertrophic differentiation of human MSCs (hMSCs). In this study, we investigated the role of endogenously...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2010
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(10)60086-6